Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate

Julia Deschamp (1) , Olivier Chuzel (1) , Jérôme Hannedouche (1) , Olivier Riant (1)

1 Laboratoire de Chimie Organique et Médicinale

A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo-, diastereo-, and enantioselectivity.

Mots clés: aldol reaction; copper; enantioselectivity; enolates; hydrosilylation

Domaines: Chimie organique

Julia Deschamp, Olivier Chuzel, Jérôme Hannedouche, Olivier Riant. Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate. Photography. France. 2006. ⟨medihal-01722925⟩