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Cette collection présente les travaux de recherche des membres de l’Institut de Chimie Organique et Analytique. Le laboratoire est une unité mixte de recherche (UMR 7311) sous la tutelle de l'Université d'Orléans et du CNRS.
Les axes de recherche développés au sein de l’ICOA sont orientés vers la conception, la synthèse et l'analyse de molécules susceptibles de présenter une activité dans le domaine des sciences du vivant.
Le laboratoire est membre de :- la fédération de recherche "Physique et Chimie du Vivant" FR CNRS 2708
- du Labex SynOrg
- du Labex IRON
L'ICOA est également laboratoire correspondant du Commissariat à l’Energie Atomique et aux énergies alternatives (CEA) LRC M09.
Le laboratoire est dirigé par Sylvain ROUTIER.
Mise à jour : Décembre 2021
Nombre de références bibliographiques
Nombre de documents avec texte intégral
331
Open Acess
Derniers dépôts (texte intégral)
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Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret, et al.. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩. ⟨hal-04575964⟩
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Nicolas Drouin, Marlien van Mever, Wei Zhang, Elena Tobolkina, Sabrina Ferre, et al.. Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation. Analytical Chemistry, 2020, 92 (20), pp.14103-14112. ⟨10.1021/acs.analchem.0c03129⟩. ⟨hal-04303264⟩
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Damien Bretagne, Arnaud Pâris, David Matthews, Laëtitia Fougère, Nastassja Burrini, et al.. ‘Mix and Match’ auto-assembly of glycosyltransferase domains delivers biocatalysts with improved substrate promiscuity. Journal of Biological Chemistry, 2024, 300 (3), pp.105747. ⟨10.1016/j.jbc.2024.105747⟩. ⟨hal-04456971⟩
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Abdelaziz Ejjoummany, Rabia Belaroussi, Ahmed El Hakmaoui, Mohamed Akssira, Gérald Guillaumet, et al.. Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions. Molecules, 2018, 23 (11), pp.2740. ⟨10.3390/molecules23112740⟩. ⟨hal-04451447⟩
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Andreea-Teodora Pânzariu, Maria Apotrosoaei, Ioana Mirela Vasincu, Maria Drăgan, Sandra Constantin, et al.. Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester. Chemistry Central Journal, 2016, 10, pp.6. ⟨10.1186/s13065-016-0151-6⟩. ⟨hal-04451478⟩
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Ioana-Mirela Vasincu, Maria Apotrosoaei, Sandra Constantin, Maria Butnaru, Liliana Vereștiuc, et al.. New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile. BMC Pharmacology and Toxicology, 2021, 22, pp.10. ⟨10.1186/s40360-021-00475-0⟩. ⟨hal-04451414⟩
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Maria Apotrosoaei, Ioana Vasincu, Maria Dragan, Frédéric Buron, Sylvain Routier, et al.. Design, Synthesis and the Biological Evaluation of New 1,3-Thiazolidine-4-ones Based on the 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one Scaffold. Molecules, 2014, 19 (9), pp.13824-13847. ⟨10.3390/molecules190913824⟩. ⟨hal-04451495⟩
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Ioana Vasincu, Maria Apotrosoaei, Andreea-Teodora Panzariu, Frédéric Buron, Sylvain Routier, et al.. Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid. Molecules, 2014, 19 (9), pp.15005-15025. ⟨10.3390/molecules190915005⟩. ⟨hal-04451507⟩
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Aisling Chaney, Francisco Lopez-Picon, Sophie Serrière, Rui Wang, Daniela Bochicchio, et al.. Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study. Theranostics, 2021, 11 (14), pp.6644-6667. ⟨10.7150/thno.56059⟩. ⟨hal-04451404⟩
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Laura Foucault-Fruchard, Aurélie Doméné, Guylène Page, Marguerite Windsor, Patrick Emond, et al.. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model. Neuroscience, 2017, 356, pp.52-63. ⟨10.1016/j.neuroscience.2017.05.019⟩. ⟨hal-04483971⟩
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Sandra Constantin, Florentina Geanina Lupascu, Maria Apotrosoaei, Ioana Mirela Vasincu, Dan Lupascu, et al.. Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold. Chemistry Central Journal, 2017, 11, pp.12. ⟨10.1186/s13065-017-0241-0⟩. ⟨hal-04451451⟩
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Jonathan Elie, Johnny Vercouillie, Nicolas Arlicot, Lucas Lemaire, Rudy Bidault, et al.. Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, $in\ vitro$ studies, radiochemistry and evaluations in rats of a [$^{18}$F] PET tracer. Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1-7. ⟨10.1080/14756366.2018.1501043⟩. ⟨hal-04451440⟩
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Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, et al.. Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold. International Journal of Molecular Sciences, 2021, 22 (13), pp.7079. ⟨10.3390/ijms22137079⟩. ⟨hal-04451412⟩
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