Prévisualisation

 

Licence


Domaine public

Partager

Lien

Métriques

Consultations de la notice

86

Téléchargements de fichiers

173

Acyl Transfer Strategies as Transient Activations for Enantioselective Synthesis

2019-04-15

Description : In order to circumvent reactivity or selectivity issues associated with the addition of enolates to electrophiles, chemists have devised innovative methods involving transient activating groups. One of these powerful methods consists of the use of activated ketones, such as -nitroketones, -dicarbonyl compounds or -ketosulfones, with electrophiles possessing a latent hydroxy or amine function. In the presence of a suitable catalyst, an enantioselective addition to the electrophile is facilitated triggering a subsequent Claisen-type fragmentation resulting in an acyl transfer. This subsequent step unveils the desired mono-activated function while directly transferring the ketone, forming in situ on the other side an ester or an amide.
Domaine :


https://medihal.archives-ouvertes.fr/medihal-02279710
Contributeur : Gaelle Chouraqui <>
Soumis le : jeudi 5 septembre 2019 - 14:58:08
Dernière modification le : dimanche 8 septembre 2019 - 22:24:12