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Enantioselective Ir-Catalyzed Bidirectional Reductive Coupling

2019-01-08

Description : In the presence of a chiral iridium complex, commercially available 3-chloro-2-chloromethyl-1-propene (1) was selectively activated for various reductive couplings. Depending on the reaction conditions it allows a selective mono- or bidirectional condensation with one or two external aldehydes with excellent enantiocontrol (>90% ee). This approach occurring simply under mild conditions and avoiding premetalated reagents constructs rapidly chiral homoallylic alcohols, key precursors of important molecular fragments such as furans, pyrans, ketodiols, or 1,3,5-polyols.
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https://medihal.archives-ouvertes.fr/medihal-01987324
Contributeur : Gaelle Chouraqui <>
Soumis le : lundi 21 janvier 2019 - 09:42:21
Dernière modification le : lundi 4 mars 2019 - 14:04:10