Chemoselective Organoclick–Click Sequence

Mokhtaria Belkheira (1, 2, 3) , Douniazad El Abed (2) , Jean-Marc Pons (1) , Cyril Bressy (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 Laboratoire de Chimie Fine
3 Université Tahri Mohamed Bechar [Bechar]

A highly chemoselective bis-triazole synthesis based on a sequence organocatalyzed click reaction/copper-catalyzed click reaction is described in this paper. A range of bis-azides react with various ketones using proline catalysis through the aryl azide moiety while the alkyl azide one remains available for a metal-catalyzed triazole synthesis.

Mots clés: triazoles; organocatalysis; orgaanoclick reaction; click reaction; chemoselectivity

Domaines: Chimie organique

Mokhtaria Belkheira, Douniazad El Abed, Jean-Marc Pons, Cyril Bressy. Chemoselective Organoclick–Click Sequence. Drawing. France. 2018. ⟨medihal-01968860⟩