Organo- and Copper-Multi-Catalyzed Pseudo Four-Component Access to gem -Difluorohydrins
Résumé
A new efficient multi‐catalytic pseudo four‐component strategy combining an aldehyde, a β‐keto‐acid and two equivalents of a fluorinating agent has been designed. Thanks to the combined effects of a secondary amine as organocatalyst and a copper catalyst, highly volatile gem‐difluorinated intermediates can be produced and trapped in situ by a chemo‐compatible decarboxylative aldolization providing a rapid access to original gem‐difluorinated β‐aldol building blocks.